Groundbreaking research from Griffith University’s National Centre for Neuroimmunology and Emerging Disease (NCNED) has revealed that COVID-19 can leave a "silent" and lasting imprint on the brain. Using advanced multimodal MRI techniques, scientists discovered that the virus causes structural and chemical changes not only in those suffering from Long COVID but also in individuals who believe they have fully recovered.
Key Discovery: The "Silent" Neurological Impact
The study compared individuals who had contracted COVID-19 against a healthy control group. The findings challenge the idea that recovery from the respiratory phase of the virus means a complete return to health.
- Grey and White Matter Alterations: Researchers found significant changes in regions of the brain responsible for memory, cognition, and executive function.
- Neurochemical Shifts: The unique MRI approach detected altered levels of brain chemicals and signal intensities that are typically invisible on standard scans.
- Persistent Effects: Even participants who reported no ongoing symptoms showed detectable changes in brain tissue structure.
Explaining "Brain Fog" and Cognitive Decline
Many patients report concentration and memory issues (often called "brain fog") months or years after infection. This study provides a biological explanation for those symptoms.
| Affected Area | Nature of Change | Impact on Patient |
| Tissue Structure | Microstructural damage in grey/white matter | Slower processing and memory gaps |
| Neurochemicals | Alterations in brain chemistry balance | Mood changes and cognitive fatigue |
| Signal Intensity | Fluctuations in brain activity patterns | Difficulty with focus and concentration |
Implications for Long COVID
The research established a direct link between the severity of initial symptoms and the extent of brain tissue alteration in Long COVID patients. This suggests that the more severe the infection, the more likely the virus is to leave a lasting neurological signature.
"The data shows that brain tissue alterations directly mirror symptom severity, proving that the virus doesn't just pass through—it may leave a lasting, hidden impact on long-term brain health." — Dr. Kiran Thapaliya, Lead Author
Professor Sonya Marshall-Gradisnik, Director of NCNED, emphasized that using state-of-the-art MRI technology is transformative for understanding how to improve the lives of those suffering from post-viral neurological issues.
Disclaimer: This content is published only for health awareness and informational purposes. It's not a substitute for your professional medical advice. You must consult a doctor/healthcare professional regarding your specific health concerns.
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