Published in Science Advances, the research reveals that long-term exposure to extremely low doses of THC (the psychoactive component of cannabis) can significantly mitigate the harmful side effects of both the virus and its life-saving treatment.
A "Too Good to Be True" Discovery
Researchers spent three years analyzing hundreds of metabolites in animal models that closely mimic human HIV patients on ART. The lead author, Dr. Lakmini Premadasa, admitted she was initially skeptical of the results.
"There were no downsides," Dr. Premadasa said. "I kept looking because I couldn’t believe it could all be good, but I really could not find any negative impacts."
Key Findings: Better Health, Same Viral Control
The study compared two groups: one receiving ART alone and another receiving ART plus daily micro-doses of THC. The results were striking:
- Liver Protection: The THC group showed lower concentrations of ART drugs in their bloodstream. This indicates that THC helps the body metabolize the medication more efficiently, potentially shielding the liver from the long-term toxicity typically associated with ART.
- Reduced Inflammation: Chronic inflammation, which often leads to cardiovascular and neurological diseases in HIV patients, was notably lower in those treated with THC.
- Metabolic Boost: Treated subjects showed lower cholesterol and toxic bile acids, alongside a significant spike in serotonin, which regulates mood and digestion.
- Total Viral Suppression: Crucially, the addition of THC did not interfere with the primary goal of ART; the virus remained undetectable in both groups.
Bridging the Gap in HIV Care
"People living with HIV experience chronic inflammation, which leads to many co-morbidities," explained Professor Mahesh Mohan, the study's senior author. His lab is focused on "therapeutic" microdosing—using amounts far below what is needed for euphoria to target specific biological pathways.
By proving that THC can act as a metabolic "tuner" without compromising the efficacy of antiretroviral drugs, this research opens the door for new supplemental therapies that could improve the quality of life for millions of people living with HIV.
Disclaimer: This content is published only for health awareness and informational purposes. It's not a substitute for your professional medical advice. You must consult a doctor/healthcare professional regarding your specific health concerns.
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